RGS integrates a paradigm of action execution with motor imagery and action observation [1, 2] where the underlying hypotheses is that functional recovery can be promoted by capitalizing on the life-long plasticity of the brain and the assumption that neuronal plasticity is governed by only a few computational principles or objectives . The. hypothesis behind the choice to combine movement execution with the observation of correlated action of virtual limbs in a first-person perspective is that , within this specific scenario, recovery can be accelerated and enhanced by driving the so called, mirror neuron system (MNS)  that can be seen as an interface between the neuronal substrates of visual perception and motor planning and execution . We hypothesize that the MNS can define a task and context relevant state of the afferent and efferent pathways that are disrupted by the lesion inducing conditions for functional recovery and rescue. As a rehabilitation and diagnostics technology RGS incorporates essential features of successful rehabilitation while reducing the need for direct supervision by therapists and clinicians.
The clinical trials that have been performed thus far suggest that RGS accelerates recovery of acute and chronic stroke while it is at least as effective in recovery of movement speed as intense – and therapist dependent - occupational therapy [1, 2]
 Belén Rubio Ballester, Jens Nirme, Esther Duarte, Ampar Cuxart, Susana Rodriguez, Paul Verschure and Armin Duff (2015), “The visual amplification of goal-oriented movements counteracts acquired non-use in hemiparetic stroke patients”, Journal of NeuroEngineering and Rehabilitation, 12:50 ; doi 10.1186/s12984-015-0039-z.
 Grechuta, K, Rubio, B, Duff, A, Duarte Oller, E, and Verschure, P (2014), “Intensive language-action therapy in virtual reality for a rehabilitation gaming system“, Proc. 10th Intl Conf. on Disability, Virtual Reality and Assoc. Technologies, PM Sharkey, L Pareto, J Broeren, M Rydmark (Eds), pp. 265-273, Gothenburg, Sweden, 2-4 Sept. 2014
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 Rodriguez, S., Bermudez i Badia, S., Cameirão, M. S., Fina, A. C., Duarte, E., Duff, A., Verschure, P. F. M. J., et al. (2011). “Effects of Virtual Reality Upper Limb Based Training (Rehabilitation Gaming System) on Spasticity, Shoulder Pain, and Depression After Stroke”. 2011 AAPM&R annual assembly (Vol. 3, p. S160). Elsevier Inc. doi:10.1016/j.pmrj.2011.08.013.
 Nirme, J., A. Duff, and P.F.M.J. Verschure. “Adaptive rehabilitation gaming system: On-line individualization of stroke rehabilitation”. in Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE. 2011. IEEE.
 Verschure, P. F. M. J. (2011). “Neuroscience, virtual reality and neurorehabilitation: brain repair as a validation of brain theory”. Conference proceedings for the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. (Vol. 2011, pp. 2254–7). IEEE.
 Nirme, J., Duff A., & Verschure P.F.M.J. (2012) “Adaptive Enhanced Mapping Of Upper Limb Movement In A Virtual Reality System For Stroke Rehabilitation”. Conference Abstract presented at the 8th FENS Forum of Neuroscience, Barcelona, Spain.
 Rubio, B., Nirme, J., Duarte, E., Cuxart, A., Rodriguez, S., Duff, A., & Verschure, P. F. M. J. (2013). “Virtual Reality Based Tool for Motor Function Assessment in Stroke Survivors”. In J. L. Pons, D. Torricelli & M. Pajaro (Eds.), Converging Clinical and Engineering Research on Neurorehabilitation (Vol. 1, pp. 1037-1041): Springer Berlin Heidelberg.
 Nirme, J., Rubio, B., Duff, A., Duarte, E., Rodriguez, S., Cuxart, A., & Verschure, P. F. M. J. (2013). “At Home Motor Rehabilitation in the Chronic Phase of Stroke Using the Rehabilitation Gaming System”. In J. L. Pons, D. Torricelli, & M. Pajaro (Eds.), Converging Clinical and Engineering Research on Neurorehabilitation SE – 151 (Vol. 1, pp. 931–935). Berlin: Springer Berlin Heidelberg.
 Duff, J. Nirme, B.Rubio, E. Duarte, A. Cuxart, S. Rodríguez, P.F.M.J. Verschure “The optimal dosage of the Rehabilitation Gaming System: The impact of a longer period of virtual reality based and standard occupational training on upper limb recovery in the acute phase of stroke”. Abstract presented during the 22nd European Stroke Conference 2013, LONDON, UK.
 Ballester, B. R., Nirme, J., Duarte, E., Cuxart, A., Rodriguez, S., Verschure, P., & Duff, A. (2015). “The visual amplification of goal-oriented movements counteracts acquired non-use in hemiparetic stroke patients“. Journal of neuroengineering and rehabilitation, 12(1), 50.
 Prochnow, D., Bermudez I Badia, S., Schmidt, J., Duff, A., Brunheim, S., Kleiser, R., Seitz, R., et al. “A functional magnetic resonance imaging study of visuomotor processing in a virtual reality-based paradigm: Rehabilitation Gaming System“. The European journal of neuroscience, (January), 1–7, 2013.
 Mónica S. Cameirão, Sergi Bermúdez i Badia, Esther Duarte, Antonio Frisoli, and Paul F.M.J. Verschure. The combined impact of Virtual Reality Neurorehabilitation and its interfaces on upper extremity functional recovery in patients with chronic stroke. “Stroke”, vol. 43 (10) 2720-2728, 2012